Day 2 at Old Trafford closed with Lancashire on 22/0 in response to Glamorgan's 344, with half-centuries for Dan Douthwaite (61) and Callum Taylor (58).
Douthwaite recorded his second half-century of the season on his return to the side, and had to dig in against tight bowling from James Anderson, Luke Wood, and Matt Parkinson, before freeing his arms on his way to his side's second top score as rain continued to hamper the efforts of the batting side.
"We're very happy with the way the day panned out, but a shame it couldn't happen earlier with the weather and we could have had a go at them from around lunchtime.
"At the start of my innings I didn't feel my free-flowing self and my bestie Kiran Carlson said I was batting with an asparagus at one point and that's a first. When the ball got older it got easier but we all found it hard to start.
With one of cricket's greatest ever players operating from his own end at Old Trafford, it was a stern examination for Glamorgan's batsmen, and one Douthwaite was happy to have been through.
"It's one off the bucket-list batting against Jimmy Anderson, just as tough as I thought with no freebies, it's an amazing experience facing someone of that calibre and that's what you play the game for.
"I'm happy with the way things are going getting fifties but I'd like to kick on and hit my first century for the club this season."